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A Paper by Dr. Abe et al. Published in Frontiers in Aging Neuroscience

A Paper by Nobuhito Abe (Assoc. Professor), Yuki Otsuka (Research Fellow), Ryusuke Nakai (Senior Lecturer), Kohei Asano (Research Fellow) and Sakiko Yoshikawa (Professor) was published in Frontiers in Aging Neuroscience.

Working memory (WM) – related brain activity is known to be modulated by aging; particularly, older adults demonstrate greater activity than young adults.  However, it is still unclear whether the activity increase in older adults is also observed in advanced aging.  The two groups of older adults- “young-old” (61-70 years old) and “old-old” (77-82 years old) were scanned while performing a visual WM task. WM effects common to both age groups were identified in several regions, including the bilateral dorsolateral prefrontal cortex (DLPFC), the inferior parietal cortex, and the insula. Greater WM effects in the old–old than in the young–old group were identified in the right caudal DLPFC.
The present findings suggest that cortical over-recruitment occurs in advanced old age, and that increased activity may serve a compensatory function in mediating WM performance.



Suzuki M, Kawagoe T, Nishiguchi S, Abe N, Otsuka Y, Nakai R, Asano K, Yamada M, Yoshikawa S, Sekiyama K (2018)
Neural correlates of working memory maintenance in advanced aging: Evidence from fMRI

Frontiers in Aging Neuroscience 10: 358

Click the image to read the paper